These involve the cooperation between members to provide mutual help and support to each other in a practical and focused form. This activity involves members helping each other to identify solutions to known problems at nuclear power plants. They are conducted at the request of a member to their Regional Centre, which organises the mission.

Technical support missions consist of a small team of experienced nuclear staff from other members, who apply their experience to propose solutions to problems, or areas for improvement previously identified through self-evaluation or WANO peer reviews.

Technical support missions have been requested for a variety of areas, such as outages, on-line maintenance, radiation protection and waste management. At the end of a mission, the team briefs the host member, giving suggestions or solutions for resolving the original problem.